Endocrine Abstracts

Bariatric surgery significantly reduces obesity-related comorbidities. Secondary hyperparathyroidism (SHPT), due to calcium malabsorption and vitamin D deficiency, has been frequently reported, however, in patients after bariatric surgery. Whether chronic SHPT after bariatric surgery could ultimately evolve into tertiary hyperparathyroidism has not been clarified. Here, we report a 59-old-woman who presented with osteoporosis (T score at the lumbar spine -4.1 and T score at th...

66-year old woman came first for an evaluation of nodular thyroid disease. Primary hyperparathyroidism (PHPT) was incidentally diagnosed during the entrance lab test with total calcium 2.62 mmol/l and PTH 93 ng/l. Serum creatinine was normal and 25 OH vitamin D was 97 nmol/l. Dual-energy X-ray absorptiometry was carried out and revealed osteoporosis at lumbar spine. Moreover, there were two low-trauma fractures in a recent patient history. Although hypercalcemia was mild, the ...

18F-fluorocholine positron emission tomography/X-ray computed tomography (PET-CT) was carried out in our patients with primary hyperparathyroidism (PHPT) and inconclusive preoperative neck ultrasound and 99Tc-sestaMIBI scintigraphy to localize abnormal parathyroid glands before surgery. The results were retrospectively evaluated and compared to postoperative histopathological findings. A total of 9 patients (1 man, 8 women) with sporadic PHPT was enrolled...

Abstract: The incidence of multiglandular parathyroid disease (MGD) varies in the range 7–33%. Negative preoperative imaging is a strong predictor of MGD in patients with primary hyperparathyroidism (PHPT). We retrospectively evaluated a cohort of 13 patients with PHPT and inconclusive MIBI scintigraphy and/or neck ultrasound (mean age 64 years, total calcium 2.74 mmol/l and parathyroid hormone (PTH) 114 ng/l). All subjects subsequently underwent additional imaging with f...

Denosumab discontinuation leads to loss of bone mineral density (BMD) achieved with treatment and in some patients to multiple vertebral fractures (VFx). Beyond bone, antiresorptive agents such as denosumab may affect breast cancer biology. We report a 69-year-old woman treated with the aromatase inhibitor anastrazole for breast cancer who suffered from five spontaneous vertebral fractures after denosumab cessation. Initially, she received four years of ibandronate followed by...

Background: By using new treatment modalities in DM1 patients (glucose sensors, insulin pumps) we quite often do not reach optimal results.Objective: As a part of the project developing software for smartphones (a self-learning diabetes management advisory tool) we provided in insulin pump users detail diet and RT-CGM records analysis. As the main cause of postprandial hyperglycaemia in our DM1 patients we identified dietary mistakes. Moreover diet of ou...

Pituitary MRI is widely used in endocrine practice, and is regarded as entirely safe. We report here a life-threatening outcome from a routine pituitary MRI scan.A 23-year-old female with a 3-year history of microprolactinoma confirmed by MRI underwent a routine repeat MRI scan with gadolinium. During injection of Gadovist she experienced minimal chest tightness which rapidly resolved. Four hours after the injection she rapidly became very breathless. On...

Background: Klinefelter Syndrome (KS) affects approximately 1 in 500 males and presents with different phenotypes. KS affects spermatogenesis and causes infertility but can also impact neurocognitive and psychological development or affect other systems like cardiovascular, dental, skeletal. European Academy of Andrology has published recommendations regarding holistic KS management, including the fertility aspects, from childhood until adulthood.<p class=...

Introduction: Hot flashes and night sweating are the most common medical complaints in women during the menopausal transition and they are strongly associated with the presence of perimenopausal depression. The pathophysiology of hot flashes has not been elucidated. Peripheral vasodilation and increase in skin temperature observed in women with hot flashes might be induced by changes in brain neurotransmitters and instability in the hypothalamic thermoregulatory center due to ...

Osteoprotegerin (OPG) is a potent inhibitor of osteoclastic bone resorption. Besides osteoblasts, OPG is expressed by both endothelial and vascular smooth muscle cells. Moreover, elevated serum OPG has been found in conditions associated with insulin resistance such as obesity, diabetes and/or Cushing syndrome.The aim of the present study was to investigate the relationship between serum OPG and insulin resistance in women with polycystic ovary syndrome ...